痛风素质的临床与生化表现：尿酸结石与单纯钙结石形成的比较
Clinical and biochemical presentation of gouty diathesis: comparison of uric acid versus pure calcium stone formation.
作者信息
Khatchadourian J, Preminger G M, Whitson P A, Adams-Huet B, Pak C Y
机构信息
Center for Mineral Metabolism, University of Texas Southwestern Medical Center at Dallas 75235-8885, USA.
出版信息
J Urol. 1995 Nov;154(5):1665-9. doi: 10.1016/s0022-5347(01)66743-0.
PURPOSE
We compared gouty diathesis with uric acid versus calcium stones.
MATERIALS AND METHODS
We retrospectively reviewed clinical and laboratory data from 95 gouty diathesis patients (28 with uric acid and 67 with calcium stones) and 99 normal subjects.
RESULTS
Of the gouty diathesis patients gouty arthritis was present in 21% of those with uric acid and 12% of those with calcium stones. Hyperuricemia developed in 43% of those with uric acid and 27% of those with calcium stones, and 2% of controls. Urinary pH was independent of the net gastrointestinal absorption of alkali in the gouty diathesis groups. Urinary pH and citrate increased after potassium citrate treatment.
CONCLUSIONS
The characteristic features of primary gout were present in both gouty diathesis groups and both are responsive to treatment.
目的
我们比较了尿酸与钙结石的痛风素质。
材料与方法
我们回顾性分析了95例痛风素质患者（28例尿酸结石患者和67例钙结石患者）及99例正常受试者的临床和实验室数据。
结果
在痛风素质患者中，尿酸结石患者痛风性关节炎的发生率为21%，钙结石患者为12%。尿酸结石患者高尿酸血症的发生率为43%，钙结石患者为27%，对照组为2%。痛风素质组的尿pH值与胃肠道碱的净吸收无关。枸橼酸钾治疗后尿pH值和枸橼酸盐增加。
结论
两个痛风素质组均存在原发性痛风的特征，且二者对治疗均有反应。
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