Kuwahara M, Marumo F
Second Department of Internal Medicine, Tokyo Medical and Dental University.
Nihon Rinsho. 1995 Aug;53(8):1873-8.
Renal tubular and interstitial cells produce various hormones. Renin is synthesized in juxtaglomerular cells which are derived from the media of the afferent arteriole. Endothelin-1 is formed in mesangial cells of glomeruli and inner medullary collecting duct. In contrast, endothelin-3 synthesis is observed in glomeruli and all the tubule segments. 1 alpha-hydroxylase is present in proximal tubule and catalyzes production of 1,25(OH)2D. PGE2 is synthesized in glomeruli, all the tubule segments, and interstitial cells. The major production sites of PGF2 alpha and 6-keto-PGF1 alpha are glomeruli and medullary collecting duct. Kallikreins are mainly produced in connecting tubule. The cells responsible for erythropoietin synthesis are thought to be interstitial cells which are localized around the proximal tubule.
肾小管和间质细胞产生多种激素。肾素在球旁细胞中合成，球旁细胞来源于入球小动脉的中膜。内皮素-1在肾小球系膜细胞和髓质内集合管中形成。相比之下，在肾小球和所有肾小管节段中都可观察到内皮素-3的合成。1α-羟化酶存在于近端小管中，催化生成1,25(OH)2D。前列腺素E2在肾小球、所有肾小管节段和间质细胞中合成。前列腺素F2α和6-酮-前列腺素F1α的主要产生部位是肾小球和髓质集合管。激肽释放酶主要在连接小管中产生。负责合成促红细胞生成素的细胞被认为是位于近端小管周围的间质细胞。
