Yoshida M
Division of Organtransplantation, Hachioji Medical Center of Tokyo Medical College.
Nihon Rinsho. 1995 Aug;53(8):1974-80.
Typical renal histological findings of Wegener's granulomatosis (WG) indicate a pauciimmune focal necrotizing glomerulonephritis with periglomerular granuloma and marked inflammatory cell infiltration in the interstitium. The recognition of the association between C (proteinase-3) anti-neutrophil cytoplasmic antibody (C [PR-3] ANCA) and WG is the only tool available to aid in the assessment of disease activity. Stage adapted immunosuppressive therapy (glucocorticoids and cyclophosphamide) has significantly altered the outcome of this once fatal disease. There are four categories of renal disease in Sarcoidosis (SD). 1) renal changes by abnormal calcium metabolism, 2) interstitial nephritis or granulomatous nephritis, 3) glomerulonephritis and 4) renal vasculitis. Corticosteroid therapy yield a favorable outcome for interstitial granulomatous nephritis of SD.
韦格纳肉芽肿（WG）典型的肾脏组织学表现为寡免疫性局灶坏死性肾小球肾炎，伴有肾小球周围肉芽肿形成以及间质内显著的炎性细胞浸润。C（蛋白酶-3）抗中性粒细胞胞浆抗体（C [PR-3] ANCA）与WG之间关联的确认是目前唯一有助于评估疾病活动度的手段。根据疾病阶段调整的免疫抑制治疗（糖皮质激素和环磷酰胺）已显著改变了这种曾一度致命疾病的预后。结节病（SD）有四类肾脏疾病。1）钙代谢异常所致的肾脏改变，2）间质性肾炎或肉芽肿性肾炎，3）肾小球肾炎，4）肾血管炎。糖皮质激素治疗对SD的间质性肉芽肿性肾炎有良好疗效。
