Orikasa S, Fukuzaki A, Konda R
Department of Urology, Tohoku University School of Medicine.
Nihon Rinsho. 1995 Aug;53(8):2019-26.
Urinary tract obstruction and vesicoureteral reflux have marked effects on renal function. Renal interstitial fibrosis and glomerular hypertrophy with subsequent focal segmental glomerulosclerosis like changes are a common consequence of chronic obstruction and vesicoureteral reflux. Evidence suggests that vasoactive compounds and cytokines such as angiotensin II, nitric oxide, eicosanoids, TNF, TGF, EGF, PDGF, bFGF have a role in the hemodynamic and structural abnormalities that occur following obstruction of the urinary tract or vesicoureteral reflux. Use of modulators for these compounds appears to be beneficial for treatment of obstructive or reflux nephropathy in near future.
尿路梗阻和膀胱输尿管反流对肾功能有显著影响。肾间质纤维化和肾小球肥大以及随后出现的局灶节段性肾小球硬化样改变是慢性梗阻和膀胱输尿管反流的常见后果。有证据表明，血管活性化合物和细胞因子，如血管紧张素II、一氧化氮、类花生酸、肿瘤坏死因子、转化生长因子、表皮生长因子、血小板衍生生长因子、碱性成纤维细胞生长因子，在尿路梗阻或膀胱输尿管反流后发生的血流动力学和结构异常中起作用。使用这些化合物的调节剂在不久的将来似乎对治疗梗阻性或反流性肾病有益。
