Shibasaki T
Second Department of Internal Medicine, Jikei University School of Medicine.
Nihon Rinsho. 1995 Aug;53(8):2047-51.
It is well known that many drugs can induce tubulointerstitial nephropathy (DTIN) in the kidney. There are two kinds of onset mechanisms such as dose-dependent and allergic nephropathy. Risk factors inducing DTIN are known as aging, dehydration, preexisting renal damage, hypertension and serum electrolyte abnormalities. Treatment of DTIN is firstly to cease suggestive drugs of inducing nephropathy and then followed by diuresis, correcting serum electrolyte levels and sometimes hemodialysis or hemoadsorption to reduce the suggested drug levels in the circulation. In allergic nephropathy, high-dose glucocorticoid therapy is available for improving renal function rapidly. The prevention of DTIN is to know the patients background and monitor serum drug levels.
众所周知，许多药物可诱发肾脏的肾小管间质性肾病（药物性肾小管间质性肾病）。其发病机制有剂量依赖性和过敏性肾病两种。诱发药物性肾小管间质性肾病的危险因素包括衰老、脱水、既往肾损伤、高血压和血清电解质异常。药物性肾小管间质性肾病的治疗首先是停用诱发肾病的可疑药物，然后进行利尿、纠正血清电解质水平，有时还需进行血液透析或血液吸附以降低循环中可疑药物的水平。在过敏性肾病中，大剂量糖皮质激素治疗可迅速改善肾功能。药物性肾小管间质性肾病的预防在于了解患者背景并监测血清药物水平。
