Hirnle P, Ziolko E
Department of Gynecology, University of Tübingen, Germany.
Lymphology. 1995 Jun;28(2):73-7.
Three young women with Hodgkin lymphoma (stage III and IV) had residual retroperitoneal lymphoma after 6 cycles of standard chemotherapy. To preserve fertility, chemotherapy was subsequently continued as a single endolymphatic injection of 60 mg Bleomycin in oily suspension (Oil Bleo). Except for slight, transient fever in one patient, no side effects occurred. Follow-up plain X-rays with lipoidal stained lymph nodes showed a marked reduction in size of the retroperitoneal lymphomatous lymph nodes in all 3 patients. Each woman became pregnant between 2 and 14 months after endolymphatic therapy and bore healthy infants. Two of the women remain free of disease. The third has had a recurrence in the neck and has been treated with second-line intravenous chemotherapy. Endolymphatic therapy of retroperitoneal lymphoma may achieve a satisfactory result in selected patients while preserving fertility.
三名患有霍奇金淋巴瘤（III期和IV期）的年轻女性在接受6个周期的标准化疗后，腹膜后淋巴瘤仍有残留。为了保留生育能力，随后继续进行化疗，采用单次经淋巴管注射60毫克平阳霉素油悬液（油剂平阳霉素）。除一名患者出现轻微、短暂发热外，未发生其他副作用。随访时对脂质染色淋巴结进行的X线平片显示，所有3例患者的腹膜后淋巴瘤性淋巴结大小均显著缩小。每名女性在经淋巴管治疗后的2至14个月内怀孕，并生下健康婴儿。其中两名女性仍无疾病复发。第三名女性颈部复发，已接受二线静脉化疗。腹膜后淋巴瘤的经淋巴管治疗在部分患者中可取得满意效果，同时保留生育能力。
