Slater R, Smit E, Kroes W, Bellomo M J, Mühlematter D, Harbott J, Behrendt H, Hählen K, Veerman A J, Hagemeijer A
Institute of Human Genetics, University of Amsterdam, The Netherlands.
Leukemia. 1995 Oct;9(10):1613-9.
A comparison of cytogenetical data on acute lymphoblastic leukaemia studied at four large European centres has revealed a non-random dicentric chromosome abnormality: dic(9;20) (p1?3;q11) in 10 patients, nine of whom were children. All had early precursor-B lineage ALL, and eight children had a non-standard risk clinical presentation. The origin of the dicentric chromosome was demonstrated using a range of chromosome banding techniques. This was confirmed by FISH using paints and centromeric probes for chromosomes 9 and 20, together with a number of cosmid probes. The follow-up time of these patients is presently too short and the number of patients too few to determine the prognostic significant of this chromosome abnormality.
10例患者存在dic(9;20)(p1?3;q11)，其中9例为儿童。所有患者均为早期前体B系急性淋巴细胞白血病，8名儿童有非标准风险的临床表现。使用一系列染色体显带技术证实了双着丝粒染色体的起源。通过荧光原位杂交（FISH），使用9号和20号染色体的涂染探针、着丝粒探针以及一些黏粒探针，进一步证实了这一结果。目前这些患者的随访时间过短，患者数量过少，尚无法确定这种染色体异常对预后的影响。
