Kamei J, Saitoh A, Morita K, Nagase H
Department of Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Life Sci. 1995;57(16):PL231-5. doi: 10.1016/0024-3205(95)02115-y.
The effect of buprenorphine on the antitussive effect of morphine was examined in mice. Buprenorphine at doses of 0.1, 0.3 and 1 mg/kg given i.p. alone have no effects on the % inhibition in the number of capsaicin-induced coughs. However, pretreatment with the same doses of buprenorphine for 2 hr significantly attenuated the antitussive effect of morphine (3 mg/kg, i.p.). Naloxonazine, a selective mu 1-opioid receptor antagonist, had no effect of buprenorphine on antitussive effect of morphine. These results suggest that buprenorphine antagonizes the antitussive effect of morphine via the activation of mu 1-opioid receptors.
