Pan J, Chan E K, Cheta D, Schranz V, Charles M A
University of California, Department of Medicine, Irvine 92717-4065, USA.
Life Sci. 1995;57(16):1525-32. doi: 10.1016/0024-3205(95)02125-3.
Glimepiride is an oral sulfonylurea drug; nicotinamide is an inhibitor of poly (ADP-ribose) synthetase and a precursor of NAD. Three studies were carried out to determine whether glimepiride and/or nicotinamide could prevent diabetes in BB rats. In Study I, we administered glimepiride treatment 200 mg/kg/day orally from the 35th to 143rd day of age. The incidence of diabetes in the glimepiride group was lower than in the control group (32% vs 55%, p < 0.02). In Study II, the treatment period was from the 35th to 147th day of age, and rats received glimepiride combined with nicotinamide (500 mg/kg/day IP). The treatment group showed a 22% incidence of diabetes compared to 53 in controls (p < 0.03). In Study III, nicotinamide treatment alone (1000 mg/kg/day orally) and combined with glimepiride were compared to untreated controls. The treatment period was from the 35th to 167th day of age. Nicotinamide-treated rats showed a 42% incidence of diabetes compared to 60% in controls (p = NS). In the nicotinamide combined with glimepiride treatment group, a lower incidence (28%) was observed when compared to the controls (60%, p < 0.05). These findings suggest that glimepiride can prevent diabetes in BB rats; however, nicotinamide when used in young animals shows only a trend to lower the incidence of diabetes, and when combined with glimepiride, no significant effect is observed.
格列美脲是一种口服磺酰脲类药物；烟酰胺是聚（ADP - 核糖）合成酶的抑制剂和NAD的前体。进行了三项研究以确定格列美脲和/或烟酰胺是否可以预防BB大鼠患糖尿病。在研究I中，我们从35日龄至143日龄每天口服给予200mg/kg的格列美脲治疗。格列美脲组的糖尿病发病率低于对照组（32%对55%，p<0.02）。在研究II中，治疗期为35日龄至147日龄，大鼠接受格列美脲联合烟酰胺（500mg/kg/天腹腔注射）。治疗组的糖尿病发病率为22%，而对照组为53%（p<0.03）。在研究III中，将单独使用烟酰胺治疗（1000mg/kg/天口服）以及与格列美脲联合使用的情况与未治疗的对照组进行比较。治疗期为35日龄至167日龄。烟酰胺治疗的大鼠糖尿病发病率为42%，而对照组为60%（p=无显著性差异）。在烟酰胺与格列美脲联合治疗组中，与对照组（60%）相比观察到较低的发病率（28%，p<0.05）。这些发现表明格列美脲可以预防BB大鼠患糖尿病；然而，烟酰胺在幼龄动物中使用时仅显示出降低糖尿病发病率的趋势，并且与格列美脲联合使用时，未观察到显著效果。
