Barker J H, Andresen D M, Anderson G L, Schuschke D, Gu J M, Gupta S, Hjortdal V E, Derr J W, Banis J C, Acland R D
Department of Surgery, University of Louisville, KY 40292, USA.
Microsurgery. 1995;16(5):349-56. doi: 10.1002/micr.1920160512.
In this study, simulated "poor" repairs applied to transverse incisions in the iliac arteries of 40 rats were the basis for comparing the effect of variations in blood flow on thromboembolism. Using vital microscopy and digital image processing, we performed 2 experiments. In the first experiment (n = 20), the reduction of post-repair blood flow by approximately 50% resulted in an 83% reduction in the total number of emboli appearing in the microcirculation of the cremaster muscle distal to the repair. In the second experiment (n = 20), the same reduction in blood flow typically resulted in larger repair-site thrombi which required significantly more time to grow to their maximum size. We conclude that reducing pedicle artery blood flow to approximately half in our rat model during reperfusion can protect the downstream microcirculation from embolic injury without increasing the incidence of thrombotic occlusion.
在本研究中，对40只大鼠髂动脉横向切口进行模拟“不良”修复，以此为基础比较血流变化对血栓栓塞的影响。我们使用活体显微镜和数字图像处理技术进行了2项实验。在第一个实验（n = 20）中，修复后血流减少约50%，导致修复远端提睾肌微循环中出现的栓子总数减少了83%。在第二个实验（n = 20）中，相同程度的血流减少通常会导致修复部位形成更大的血栓，这些血栓生长到最大尺寸所需的时间明显更长。我们得出结论，在再灌注期间将我们大鼠模型中的蒂动脉血流减少至大约一半，可以保护下游微循环免受栓塞损伤，而不会增加血栓闭塞的发生率。
