Frost-Arner L, Bergqvist D
Department of Plastic and Reconstructive Surgery, Malmö General Hospital, Sweden.
Microsurgery. 1995;16(5):357-61. doi: 10.1002/micr.1920160513.
The effects of isovolemic hemodilution with dextran-70 and albumin on thrombus formation in artificial arterial grafts were investigated. A polytetrafluoroethylene graft (PTFE, length 13 mm, inner diameter 3 mm) was inserted into the abdominal aorta of rabbits. Three groups of animals were studied; 1) animals receiving isovolemic hemodilution with dextran-70 (10 ml/kg body weight), 2) animals receiving isovolemic hemodilution with albumin (10 ml/kg body weight), and 3) nonhemodiluted controls. The blood flow increased by about 70% and 60% after the hemodilution with dextran and albumin, respectively, and remained high in the hemodiluted animals, after insertion of the graft. After 2 days, the vessel graft was removed and weighed. The thrombus mass was separately weighed. The results suggest that isovolemic hemodilution with both albumin and dextran is associated with a marked increase in blood flow in the rabbit. Hemodilution with dextran also reduced the amount of thrombus formation on the inner wall of the graft.
研究了用右旋糖酐-70和白蛋白进行等容血液稀释对人造动脉移植物中血栓形成的影响。将聚四氟乙烯移植物（PTFE，长度13毫米，内径3毫米）插入兔腹主动脉。研究了三组动物；1）接受右旋糖酐-70等容血液稀释（10毫升/千克体重）的动物，2）接受白蛋白等容血液稀释（10毫升/千克体重）的动物，3）未进行血液稀释的对照动物。用右旋糖酐和白蛋白进行血液稀释后，血流量分别增加了约70%和60%，并且在植入移植物后，血液稀释动物的血流量保持在较高水平。2天后，取出血管移植物并称重。分别称取血栓质量。结果表明，白蛋白和右旋糖酐的等容血液稀释均与兔血流量的显著增加有关。用右旋糖酐进行血液稀释还减少了移植物内壁上血栓形成的量。
