Merello M, Leiguarda R
Instituto de Investigaciones Neurológicas Raúl Carrea, FLENI, Buenos Aires.
Medicina (B Aires). 1995;55(1):5-10.
Sixteen patients with Parkinson's disease and severe motor fluctuations were treated with subcutaneous injections of apomorphine and followed up prospectively for a year. The use of the drug improved the number of daily "off" hours by 52%, while treatment efficacy remained constant for a year without the appearance of tolerance (ANOVA with repeated measurements:p = 0.0002). No severe adverse effect or any justifying treatment discontinuance were recorded. Apomorphine proved a safe and reliable drug for the treatment of motor fluctuations.
16例患有帕金森病且存在严重运动波动的患者接受了皮下注射阿扑吗啡治疗，并进行了为期一年的前瞻性随访。使用该药物使每日“关”期时长减少了52%，且治疗效果在一年中保持稳定，未出现耐受性（重复测量方差分析：p = 0.0002）。未记录到严重不良反应或任何导致停药的合理理由。阿扑吗啡被证明是一种治疗运动波动安全可靠的药物。
