Kościelak J, Gryszkiewicz A, Schier J, Góralski S
Acta Haematol Pol. 1977 Oct-Dec;8(4):303-7.
Three preparations of hydroxyethyl starch having MS 0.55, 0.65 and 0.8 respectively and labelled with 14C in hydroxyethyl residue were administered to mice. After 1, 5, 10, 20 and 60 days the mice were sacrificed and radioactivities determined in the following organs and tissues: blood, spleen, liver, kidneys, heart, lungs and muscles. Most of the initial dose of radioactivity was eliminated from mice within 24 h. The remaining portion was eliminated slowly and even after 60 days 0 07--1.2% of the initial dose could be detected in different organs. The rate of clearance of radioactivity was fastest for hydroxyethyl starch with MS = 0.55 and slowest for the preparation with MS = 0.8. The retention of radioactivity was most conspicous in the muscles.
分别向小鼠给予三种平均取代度（MS）为0.55、0.65和0.8且羟乙基残基用¹⁴C标记的羟乙基淀粉制剂。在1、5、10、20和60天后处死小鼠，并测定以下器官和组织中的放射性：血液、脾脏、肝脏、肾脏、心脏、肺和肌肉。大部分初始放射性剂量在24小时内从小鼠体内消除。其余部分消除缓慢，甚至在60天后，仍可在不同器官中检测到初始剂量的0.07% - 1.2%。放射性清除率对于MS = 0.55的羟乙基淀粉最快，对于MS = 0.8的制剂最慢。放射性在肌肉中的保留最为明显。
