转基因小鼠脾脏中lacZ基因的自发突变频率随年龄增加而升高。
Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age.
作者信息
Ono T, Miyamura Y, Ikehata H, Yamanaka H, Kurishita A, Yamamoto K, Suzuki T, Nohmi T, Hayashi M, Sofuni T
机构信息
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Mutat Res. 1995 Oct;338(1-6):183-8. doi: 10.1016/0921-8734(95)00023-y.
Spontaneous mutant frequency of lacZ gene in spleen of transgenic MutaTM mouse was examined at different ages. It was (3.2 +/- 1.3 (SD)) x 10(-5) at newborn and increased almost linearly with age up to (8.3 +/- 1.8) x 10(-5) at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.
在不同年龄段检测转基因MutaTM小鼠脾脏中lacZ基因的自发突变频率。新生小鼠的该频率为(3.2±1.3(标准差))×10⁻⁵，且几乎随年龄呈线性增加，到一岁时达到(8.3±1.8)×10⁻⁵。由于该基因的突变在体内不太可能受到选择，这些数据支持了这样一种观点，即自发突变在整个衰老过程中都会发生，并且如果不被细胞死亡淘汰，会随着年龄的增长而积累。
Zotero 插件