Simi S, Morelli S, Gervasi P G, Rainaldi G
Genetica e Biochimica Tossicologica, Istituto di Mutagenesi e Differenziamento CNR, Pisa, Italy.
Mutat Res. 1995 Aug;347(3-4):151-6. doi: 10.1016/0165-7992(95)00034-8.
The clastogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosomal aberrations are modulated in similar manner both in parental and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.
在仅表达还原途径酶的V79中国仓鼠细胞系以及转染并表达三种大鼠细胞色素P450（1A1、1A2、2B1）的三个衍生细胞系中，研究了七种蒽醌的致断裂性。结果表明，亲代和转染的V79细胞系中染色体畸变的调节方式相似，这表明这些化合物的致断裂性不是由细胞色素P450依赖性单加氧酶介导的。
