作用于δ受体的阿片类物质可调节鸡睫状神经节培养的节后神经元中的Ca2+电流。
Opioids acting on delta-receptors modulate Ca2+ currents in cultured postganglionic neurones of avian ciliary ganglia.
作者信息
Motin L G, Bennett M R, Christie M J
机构信息
Physiology Department, University of Sydney, NSW, Australia.
出版信息
Neurosci Lett. 1995 Jun 23;193(1):21-4. doi: 10.1016/0304-3940(95)11656-h.
Opioid agonists inhibited Ba2+ currents in cultured postganglionic neurons of 3-15-day-old embryonic avian ciliary ganglia. Leucine-enkephalin (LENK, 10-20 microM) inhibited transient Ba2+ currents by 50% and sustained currents by 21%. The delta-opioid receptor agonist, DPDPE (0.02-10 microM), also inhibited Ba2+ currents, but kappa- (U50488H) and mu- (DAMGO) receptor agonists had no effect. Inhibition of Ba2+ currents showed profound desensitisation during prolonged application of agonists, being reduced to approximately 25% of the original response after 4 min superfusion with leucine-enkephalin (10-20 microM).
阿片类激动剂抑制了3至15日龄胚胎鸡睫状神经节培养的节后神经元中的Ba2+电流。亮氨酸脑啡肽（LENK，10 - 20 microM）使瞬时Ba2+电流抑制50%，使持续电流抑制21%。δ阿片受体激动剂DPDPE（0.02 - 10 microM）也抑制Ba2+电流，但κ（U50488H）和μ（DAMGO）受体激动剂没有作用。在长时间应用激动剂期间，Ba2+电流的抑制表现出明显的脱敏现象，在用亮氨酸脑啡肽（10 - 20 microM）灌注4分钟后，抑制作用降至原始反应的约25%。
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