重复给予可卡因会降低大鼠中5-羟色胺1A介导的催乳素分泌。

Repeated cocaine administration reduces 5-HT1A-mediated prolactin secretion in rats.

作者信息

Baumann M H, Rothman R B

机构信息

Clinical Psychopharmacology Section, NIDA Addiction Research Center, National Institutes of Health, Baltimore, MD 21224, USA.

出版信息

Neurosci Lett. 1995 Jun 23;193(1):9-12. doi: 10.1016/0304-3940(95)11652-d.

DOI:10.1016/0304-3940(95)11652-d

PMID:7566671

Abstract

The prolactin and behavioral responses elicited by the 5-HT1A agonist 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino]tetralin) were examined in male rats previously exposed to chronic cocaine (15 mg/kg, i.p., b.i.d., 7 days) or saline. After 42 h of withdrawal, cocaine-treated rats exhibited a reduced prolactin response to 8-OH-DPAT challenge (50 micrograms/kg, i.v.). A 5-fold higher dose of 8-OH-DPAT stimulated maximal prolactin secretion that was similar in cocaine- and saline-treated rats. Prior cocaine treatment had no effect on the 5-HT syndrome induced by 8-OH-DPAT. Our data agree with the findings of others and suggest that 5-HT1A receptors mediating neuroendocrine secretion become subsensitive after repeated cocaine administration.

摘要

在先前暴露于慢性可卡因（15毫克/千克，腹腔注射，每日两次，共7天）或生理盐水的雄性大鼠中，研究了5-羟色胺1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）引发的催乳素和行为反应。在戒断42小时后，接受可卡因治疗的大鼠对8-OH-DPAT激发（50微克/千克，静脉注射）的催乳素反应降低。高5倍剂量的8-OH-DPAT刺激的最大催乳素分泌在接受可卡因和生理盐水治疗的大鼠中相似。先前的可卡因治疗对8-OH-DPAT诱导的5-羟色胺综合征没有影响。我们的数据与其他人的研究结果一致，表明介导神经内分泌分泌的5-羟色胺1A受体在反复给予可卡因后变得不敏感。