Brittebo E B, Eriksson C
Department of Pharmacology and Toxicology, Uppsala Biomedical Centre, Sweden.
Neurotoxicology. 1995 Summer;16(2):271-80.
Following intranasal instillation of 14C-taurine in C57B1/6 mice, there was a labelling of the olfactory neuroepithelium, axon bundles and axon layers in the olfactory bulb 4 and 24 h later, suggesting an axonal migration of radioactivity to the olfactory bulbs. In the olfactory bulbs the level of radioactivity was 45-times higher than that in the posterior part of the brain. In mice treated with the olfactory toxicant dichlobenil, inducing necrosis in the dorsomedial olfactory region, there was a dose-dependent decrease in the level of 14C-taurine and 3H-carnosine (derived from the precursor 3H-beta-alanine) in the olfactory bulb. The migration of 14C-taurine in the olfactory system of dichlobenil-dosed mice gradually recovered 3 - 8 weeks later although an atypical epithelium remained in the dorsomedial portion of the olfactory region. The results suggest a transient reduction of the migration of taurine in the olfactory system of mice following chemically-induced toxicity at this site.
在C57B1/6小鼠经鼻内滴注14C-牛磺酸后，4小时和24小时后嗅神经上皮、轴突束和嗅球中的轴突层出现放射性标记，表明放射性物质向嗅球发生了轴突迁移。在嗅球中，放射性水平比脑后部高45倍。在用嗅觉毒物二氯苯腈处理的小鼠中，该药会导致背内侧嗅觉区域坏死，嗅球中14C-牛磺酸和3H-肌肽（源自前体3H-β-丙氨酸）的水平出现剂量依赖性下降。尽管在嗅觉区域的背内侧部分仍保留有非典型上皮，但在给予二氯苯腈的小鼠嗅觉系统中，14C-牛磺酸的迁移在3至8周后逐渐恢复。结果表明，该部位化学诱导毒性后，小鼠嗅觉系统中牛磺酸的迁移出现短暂减少。
