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[五个专科医院中心最常分离菌株的抗生素耐药表型。多中心研究]

[Phenotypes of resistance to antibiotics of the most frequently isolated strains in five specialized hospital centers. Multicenter study].

作者信息

Gabastou J M, Chouaki T, Mangeot J, Zemir A, Manuel C, Lepitre M, Gravisse J, Cornel E, Denis-Jacquot N, Mahuzier G

机构信息

Centre hospitalier Perray-Vaucluse, Epinay-sur-orge, France.

出版信息

Pathol Biol (Paris). 1995 Apr;43(4):320-3.

PMID:7567123
Abstract

Antibiotic susceptibility of 948 bacterial strains isolated from varied samples essentially proceeding from urinary infections in five Paris psychiatric Hospitals was determined by disk diffusion method. E. coli, P. mirabilis, Klebsiella spp., P. aeruginosa et S. aureus are the predominant bacteria. 40% of S. aureus are methicilline resistant. Enterobacteriaceae are progressively becoming resistant to aminopenicillines, but remain sensitive to third generation cephalosporines. They are still susceptible to first generation quinolones. At least, if no resistance of P. aeruginosa to imipeneme has been reported, 30% of strains are resistant to ciprofloxacine. Resistance phenotypes to antibiotics of the strains isolated in patients from psychiatric Hospitals are located between those observed in out patients and in patients from general Hospitals. However, we noticed a worrying evolution of resistance to those encontered in psychiatric Hospitals. Therefore, a multiresistant strains emergence monitoring must be carried out regulary.

摘要

采用纸片扩散法测定了从巴黎五家精神病医院各种样本中分离出的948株细菌的抗生素敏感性,这些样本主要来自泌尿系统感染。大肠杆菌、奇异变形杆菌、克雷伯菌属、铜绿假单胞菌和金黄色葡萄球菌是主要细菌。40%的金黄色葡萄球菌对甲氧西林耐药。肠杆菌科细菌对氨基青霉素的耐药性逐渐增强,但对第三代头孢菌素仍敏感。它们对第一代喹诺酮类药物仍敏感。至少,如果没有报告铜绿假单胞菌对亚胺培南耐药,30%的菌株对环丙沙星耐药。精神病医院患者分离菌株的抗生素耐药表型介于门诊患者和综合医院患者中观察到的表型之间。然而,我们注意到精神病医院中耐药性出现了令人担忧的演变。因此,必须定期进行多重耐药菌株出现情况的监测。

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