Hsu C Y, Huang L M, Lee C Y, Lin T Y, Lee P I, Chen J M
Department of Pediatrics, Taipei Municipal Maternal and Child Health Hospital, Taiwan.
Pediatr Infect Dis J. 1995 Jul;14(7):567-72. doi: 10.1097/00006454-199507000-00003.
The effect of local massage on adverse reactions and immunogenicity of diphtheria-tetanus-pertussis vaccine was investigated. After diphtheria-tetanus-pertussis vaccination 327 infants were either massaged or not, and adverse reactions were evaluated. Local pain and fever were more frequent in the massage group. The extra febrile episodes from massage were mild (38-39 degrees C). For evaluation of the antibody responses, 124 infants were recruited into massage or nonmassage cohorts and antibody production was measured at 2, 6, 7, 18 and 19 months of age, respectively. Subjects in the massage group developed significantly higher antibodies against filamentous hemagglutinin at 6 and 7 months of age, pertussis toxin at 6, 7, 18 and 19 months of age, pertussis agglutinogen at 18 and 19 months of age and those in the nonmassage group. Local massage after diphtheria-tetanus-pertussis vaccination was associated with better immunogenicity and more adverse reactions, including low grade fever and local pain, which were mild and not particularly disturbing.
研究了局部按摩对白喉-破伤风-百日咳疫苗不良反应和免疫原性的影响。327名婴儿在接种白喉-破伤风-百日咳疫苗后，一部分接受按摩，一部分未接受按摩，并对不良反应进行了评估。按摩组局部疼痛和发热更为常见。按摩引起的额外发热发作较轻（38-39摄氏度）。为了评估抗体反应，124名婴儿被纳入按摩组或非按摩组，并分别在2、6、7、18和19月龄测量抗体产生情况。按摩组婴儿在6和7月龄时针对丝状血凝素产生的抗体、在6、7、18和19月龄时针对百日咳毒素产生的抗体、在18和19月龄时针对百日咳凝集原产生的抗体均显著高于非按摩组。白喉-破伤风-百日咳疫苗接种后进行局部按摩与更好的免疫原性以及更多的不良反应相关，包括低热和局部疼痛，这些反应较轻且没有特别困扰。
