Rechlin T, Weis M, Claus D, Kaschka W P
Department of Psychiatry, University of Erlangen-Nuremberg, Psychiatrische Universitätsklinik, Germany.
Psychiatry Res. 1995 Apr 28;56(3):279-87. doi: 10.1016/0165-1781(95)02511-t.
Ninety-one patients treated with amitriptyline and 60 normal control subjects underwent a standardized heart rate analysis in supine posture. Tests included the determination of time- and frequency-derived measurements of heart rate variability. The patients differed significantly from the control subjects in all parameters investigated. Two-thirds of the patients treated with a tricyclic antidepressant (TCA) reached values that met the criteria for cardiovascular autonomic neuropathy. Our results provide evidence that heart rate analysis might be a more sensitive tool in diagnosing amitriptyline-associated anticholinergic delirium than determination of TCA plasma levels. Further research is needed to elucidate what implications the TCA-associated alteration of autonomic cardiovascular function might have for patients.
91名接受阿米替林治疗的患者和60名正常对照者接受了仰卧位的标准化心率分析。测试包括心率变异性的时间和频率衍生测量的测定。在所有研究参数中，患者与对照者有显著差异。三分之二接受三环类抗抑郁药（TCA）治疗的患者达到了符合心血管自主神经病变标准的值。我们的结果表明，心率分析可能是诊断阿米替林相关抗胆碱能谵妄比测定TCA血浆水平更敏感的工具。需要进一步研究以阐明TCA相关的自主心血管功能改变对患者可能有哪些影响。
