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[心源性休克的治疗选择]

[Therapeutic options in cardiogenic shock].

作者信息

Alonso Francia C, Calvo Cebollero I, Diarte de Miguel J A, Gomollón García J P, Placer Peralta L J

机构信息

Sección de Hemodinámica y Cardiología Intervencionista, Hospital Miguel Servet, Zaragoza.

出版信息

Rev Esp Cardiol. 1995 Sep;48(9):573-80.

PMID:7569257
Abstract

Cardiogenic shock continues to be a clinical situation which is related with high mortality. Although its etiology is varied, the most frequent cause is an acute myocardial infarction. The poor prognosis of cardiogenic shock can be favourably modified with the diagnosis of the underlying cause followed by the stabilization of the patient and early revascularization. Early treatment with inotropic or vasopressor drugs improves the condition of most patients and the use of circulatory assistance, such as the intraaortic balloon, lead to an acceptable hemodynamic situation in 80% of cases. However, they do not significantly modify the mortality rates. In addition, thrombolytic therapy does not appear to be effective for this kind of patients. Only revascularization methods have proved to be effective; surgery is the only option where ventricular septal, free wall, or papillary muscle rupture occurs, resulting in survival rates of between 50 and 60% with coronary artery by-pass surgery. Angioplasty is frequently successful in reperfusion of the infarct-related artery; the survival rate in these cases is approximately 70%, according to the different series published. As the mortality rate is exceedingly high (70-90%) when conventional therapy is used; when appropriate diagnostic and therapeutic means are available and when the patient's condition is recoverable, the attitude should be aggressive and coronary angiography and angioplasty applied as soon as possible. In centers where these means are not available, once measures have been taken to achieve the stabilization of the patient, the most suitable procedure is to transfer him or her to a hospital in which qualified staff and such treatment methods are available.

摘要

心源性休克仍然是一种与高死亡率相关的临床情况。尽管其病因多种多样,但最常见的原因是急性心肌梗死。通过诊断潜在病因,随后使患者病情稳定并尽早进行血运重建,可以改善心源性休克的不良预后。使用正性肌力药或血管升压药进行早期治疗可改善大多数患者的病情,而使用循环辅助装置,如主动脉内球囊反搏,在80%的病例中可使血流动力学状况达到可接受的水平。然而,它们并没有显著改变死亡率。此外,溶栓治疗对这类患者似乎无效。只有血运重建方法已被证明是有效的;在发生室间隔、游离壁或乳头肌破裂的情况下,手术是唯一的选择,冠状动脉搭桥手术的生存率在50%至60%之间。血管成形术在梗死相关动脉再灌注方面常常取得成功;根据已发表的不同系列研究,这些病例的生存率约为70%。由于使用传统疗法时死亡率极高(70%-90%);当有适当的诊断和治疗手段且患者病情可恢复时,应采取积极的态度,尽快进行冠状动脉造影和血管成形术。在没有这些手段的中心,一旦采取措施使患者病情稳定,最合适的做法是将其转至有合格医护人员和此类治疗方法的医院。

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