软骨藻酸对脑氨基酸水平的影响。
Effect of domoic acid on brain amino acid levels.
作者信息
Durán R, Arufe M C, Arias B, Alfonso M
机构信息
Departamento de Biología Fundamental, Facultad de Ciencias, Universidad de Vigo, Spain.
出版信息
Rev Esp Fisiol. 1995 Mar;51(1):23-7.
The administration of Domoic Acid (Dom) in a 0.2 mg/kg i.p. dose induces changes in the levels of amino acids of neurochemical interest (Asp, Glu, Gly, Tau, Ala, GABA) in different rat brain regions (hypothalamus, hippocampus, amygdala, striatum, cortex and midbrain). The most affected amino acid is the GABA, the main inhibitory amino acid neurotransmitter, whereas glutamate, the main excitatory amino acid, is not affected. The rat brain regions that seem to be the main target of the Dom action belong to the limbic system (hippocampus, amygdala). The possible implication of the amino acids in the actions of Dom is also discussed.
腹腔注射剂量为0.2mg/kg的软骨藻酸（Dom）会引起不同大鼠脑区（下丘脑、海马体、杏仁核、纹状体、皮层和中脑）中具有神经化学研究意义的氨基酸（天冬氨酸、谷氨酸、甘氨酸、牛磺酸、丙氨酸、γ-氨基丁酸）水平发生变化。受影响最大的氨基酸是γ-氨基丁酸，它是主要的抑制性氨基酸神经递质，而主要的兴奋性氨基酸谷氨酸则未受影响。似乎是Dom作用主要靶点的大鼠脑区属于边缘系统（海马体、杏仁核）。文中还讨论了氨基酸在Dom作用中的可能影响。
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