Messa G, Blardi P, La Placa G, Puccetti L, Ghezzi A
Istituto di Clinica Medica Generale e Terapia Medica, Università, Siena.
Recenti Prog Med. 1995 Jul-Aug;86(7-8):272-81.
In this study the profibrinolytic activity of two single oral doses of mesoglycan was evaluated. Furthermore, a mathematical model describing the patterns of the resulting phenomena was applied. Ten patients with impaired fibrinolytic system (euglobulin lysis time > 180 min) were enrolled in the study. In the morning following a 24 hour fast period, the patients were given orally a single dose (100 and 50 mg) of mesoglycan and placebo, with an interval of 48 hours between each treatment. The following parameters were evaluated at the time 0 and after 2, 4, 6, 8, 10 and 12 hours from each administration: tissue plasminogen activator (t-PA) and its inhibitor PAI-1, euglobulin lysis time, plasminogen and alfa-2-antiplasmin as indexes of the fibrinolytic system; aPTT, TT, fibrinogen as indexes of the hemostatic-coagulative system. Mesoglycan showed a dose-dependent profibrinolytic activity, that was also present after placebo but in a less entity. The mathematical study confirms the experimental observations and thus may allow to describe, with a high degree of approximation, the in vivo pharmacology of mesoglycan through the use of the mathematical function.
在本研究中，评估了两次单剂量口服硫酸软骨素的纤溶活性。此外，应用了一个描述所产生现象模式的数学模型。十名纤维蛋白溶解系统受损（优球蛋白溶解时间>180分钟）的患者参与了该研究。在禁食24小时后的早晨，给患者口服单剂量（100毫克和50毫克）的硫酸软骨素和安慰剂，每次治疗间隔48小时。在每次给药后的0小时以及2、4、6、8、10和12小时评估以下参数：作为纤维蛋白溶解系统指标的组织纤溶酶原激活物（t-PA）及其抑制剂PAI-1、优球蛋白溶解时间、纤溶酶原和α-2-抗纤溶酶；作为止血凝血系统指标的活化部分凝血活酶时间（aPTT）、凝血酶时间（TT）、纤维蛋白原。硫酸软骨素显示出剂量依赖性纤溶活性，安慰剂后也有这种活性，但程度较低。数学研究证实了实验观察结果，因此通过使用数学函数，可能允许高度近似地描述硫酸软骨素的体内药理学。
