Herzlinger D
Department of Physiology and Biophysics, Cornell University Medical College, New York, NY 10021, USA.
Semin Nephrol. 1995 Jul;15(4):255-62.
The conversion of intermediate mesoderm into renal tubular structures occurs throughout embryonic development from the formation of the nephric duct through to the generation of metanephric nephrons. Studies using an in vitro model system of renal epithelial morphogenesis indicate that the signals mediating tubulogenesis rescue intermediate mesoderm from programmed cell death, trigger spindle-shaped mesodermal cells to differentiate into epithelia, and lastly promote epithelial cell diversification and segmented tubule assembly. Recent data indicate that members of the Wnt family of developmental regulatory genes play an important role in the signaling pathway mediating renal epithelial morphogenesis.
从中肾管形成到后肾肾单位产生的整个胚胎发育过程中，中间中胚层都会转化为肾小管结构。使用肾上皮形态发生体外模型系统的研究表明，介导肾小管发生的信号可挽救中间中胚层免于程序性细胞死亡，触发纺锤形中胚层细胞分化为上皮细胞，最后促进上皮细胞多样化和节段性肾小管组装。最近的数据表明，发育调节基因的Wnt家族成员在介导肾上皮形态发生的信号通路中起重要作用。
