Arteaga A, Martínez A, Pollak F, Borghesi L, Catalán L, Acosta A M, Leighton F
Departamento de Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago de Chile.
Rev Med Chil. 1995 Feb;123(2):145-57.
We studied 90 male non diabetic patients aged between 40 and 65 years old with a total cholesterol of less than 240 mg/dl and not receiving cholesterol reducing drugs, that were subjected to elective coronary arteriography. Weight, height, blood pressure and smoking habits were recorded and a fasting blood sample was drawn to measure total and HDL cholesterol, triglycerides, apoproteins A1 and B, Lipoprotein(a) and plasma cholesteryl ester transfer activity. Arteriography disclosed coronary lesions in 54 patients. Compared to patients without lesions, the former had lower HDL cholesterol (34 +/- 9.8 vs 40.2 +/- 11.6 mg/dl) and higher total cholesterol/HDL cholesterol and apoB/apoA1 ratios. No differences were found for lipoprotein(a) and plasma cholesteryl ester transfer activity. Univariate analysis showed that low HDL cholesterol had the best predictive capacity for atherosclerosis.
我们研究了90名年龄在40至65岁之间的男性非糖尿病患者，他们的总胆固醇低于240mg/dl且未服用降胆固醇药物，并接受了选择性冠状动脉造影。记录了体重、身高、血压和吸烟习惯，并抽取空腹血样以测量总胆固醇和高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A1和B、脂蛋白(a)以及血浆胆固醇酯转移活性。血管造影显示54例患者有冠状动脉病变。与无病变的患者相比，前者的高密度脂蛋白胆固醇较低（34±9.8 vs 40.2±11.6mg/dl），总胆固醇/高密度脂蛋白胆固醇和载脂蛋白B/载脂蛋白A1比值较高。脂蛋白(a)和血浆胆固醇酯转移活性未发现差异。单因素分析表明，低高密度脂蛋白胆固醇对动脉粥样硬化具有最佳的预测能力。
