Codaccioni X, Puech F, Leroy J L, Switala I
Clinique de Gynécologie-Obstétrique et de Pathologie de la Reproduction, Maternité Henri-Salengro, Lille.
Rev Fr Gynecol Obstet. 1995 May-Jun;90(5-6):302-5.
Contraception during breast feeding must take two points into account: the first physiological contraception due to anovulation which disappears at around the 9th week of lactation); the second pharmacological: any substance ingested by the mother during breast feeding is excreted in milk, chiefly by passive diffusion. All pharmacokinetic studies have shown that the transfer of progesterone or of estrogen when taking a contraceptive pill is extremely slight, being of the same order as that of natural hormones. When it is decided to use hormonal contraception, this should be started after the 6th week of lactation, when lipid profile has returned to normal and thromboembolic risk is identical to that of the population in general. As with all prescription during lactation, the drug should be taken as far as possible from the next feed. Barrier techniques (combining condoms and spermicides) are an elegant alternative to drug methods.
一是由于无排卵导致的生理性避孕(这种情况在哺乳期第9周左右消失);二是药物性避孕:母亲在哺乳期摄入的任何物质都会通过被动扩散主要排泄到乳汁中。所有药代动力学研究均表明,服用避孕药时孕激素或雌激素的转移极其轻微,与天然激素的转移程度相当。当决定采用激素避孕时,应在哺乳期第6周后开始,此时血脂水平已恢复正常,血栓栓塞风险与普通人群相同。与哺乳期的所有用药一样,药物应尽可能在下次喂奶前服用。屏障技术(结合使用避孕套和杀精剂)是药物避孕方法的一种不错的替代选择。