Skarda R T, Bednarski R M, Muir W W, Hubbell J A, Mason D E
College of Veterinary Medicine, Ohio State University, Columbus, USA.
Schweiz Arch Tierheilkd. 1995;137(7):312-21.
The purpose of this study was to review the effects of sedatives and anesthetics in 137 dogs and 13 cats with congenital or acquired heart disease which were referred for diagnostic, therapeutic, and surgical interventions: correction of patent ductus arteriosus (PDA-ligation, 28%), cardiac catheterization with angiogram and angioplasty (22%), pacemaker implantation (18%), exploratory lateral thoracotomy (8.7%), correction of right aortic arch (ring anomaly, 3.3%), correction of subvalvular aortic stenosis (2.7%), correction of PDA with coil in patients with mitral regurgitation and congestive heart failure (2%), pericardectomy and removal of heart-base tumors (2%), palliative surgery for ventricular septal defect (VSD, 0.7%), and sick patients with deleterious cardiac arrhythmias (0.7%). The anesthetic plan considered the risks of anesthesia based upon preoperative patient assessment, classification scheme for functional phases of heart failure, and anesthetic drug effects of the cardiovascular system. The effects of sedatives and anesthetic drugs on determinants of cardiac output are described. The most commonly used drugs for premedication, induction, and maintenance of anesthesia were midazolam-oxymorphone (20%), thiopental or etomidate (30%), and isoflurane (64%). Prompt therapy was given to control arrhythmias and provide organ perfusion, pain relief, muscle relaxation and renal diuresis, using lidocaine, dopamine, fentanyl, atracurium, and furosemide in 17.3% 14.7%, 12%, 10%, and 8.7% of animals, respectively. Methods of routine and advanced patient monitoring are described.
本研究的目的是回顾镇静剂和麻醉剂对137只犬和13只患有先天性或后天性心脏病的猫的影响,这些动物因诊断、治疗和手术干预而被转诊:动脉导管未闭矫正术(动脉导管结扎术,28%)、心脏导管插入术及血管造影和血管成形术(22%)、起搏器植入术(18%)、 exploratory lateral thoracotomy(8.7%)、右主动脉弓矫正术(环状异常,3.3%)、瓣膜下主动脉狭窄矫正术(2.7%)、二尖瓣反流和充血性心力衰竭患者的动脉导管未闭线圈矫正术(2%)、心包切除术和心脏基部肿瘤切除术(2%)、室间隔缺损姑息手术(室间隔缺损,0.7%)以及患有有害心律失常的患病动物(0.7%)。麻醉方案根据术前患者评估、心力衰竭功能阶段分类方案以及心血管系统的麻醉药物作用来考虑麻醉风险。描述了镇静剂和麻醉药物对心输出量决定因素的影响。用于麻醉前用药、诱导和维持麻醉的最常用药物是咪达唑仑 - 羟吗啡酮(20%)、硫喷妥钠或依托咪酯(30%)和异氟醚(64%)。分别在17.3%、14.7%、12%、10%和8.7%的动物中使用利多卡因、多巴胺、芬太尼、阿曲库铵和呋塞米进行快速治疗,以控制心律失常并提供器官灌注、缓解疼痛、肌肉松弛和肾利尿。描述了常规和高级患者监测方法。