Paul R E, Packer M J, Walmsley M, Lagog M, Ranford-Cartwright L C, Paru R, Day K P
Department of Zoology, University of Oxford, UK.
Science. 1995 Sep 22;269(5231):1709-11. doi: 10.1126/science.7569897.
Description of the genetic structure of malaria parasite populations is central to an understanding of the spread of multiple-locus drug and vaccine resistance. The Plasmodium falciparum mating patterns from madang, Papua New Guinea, where intense transmission of malaria occurs, are described here. A high degree of inbreeding occurs in the absence of detectable linkage disequilibrium. This contrasts with other studies, indicating that the genetic structure of malaria parasite populations is neither clonal nor panmictic but will vary according to the transmission characteristics of the region.
疟原虫种群遗传结构的描述对于理解多位点药物和疫苗抗性的传播至关重要。本文描述了疟疾传播强烈的巴布亚新几内亚马当地区的恶性疟原虫交配模式。在没有可检测到的连锁不平衡的情况下，出现了高度的近亲繁殖。这与其他研究形成对比，表明疟原虫种群的遗传结构既不是克隆性的也不是随机交配的，而是会根据该地区的传播特征而有所不同。
