Miyata M, Sakurai M, Rikimaru A
Department of Orthopaedic Surgery, Tohoku University School of Medicine, Miyagi.
Ryumachi. 1995 Jun;35(3):521-9.
Bone mineral density (BMD) of the radius was measured in 181 female patients with rheumatoid arthritis (RA) and 255 control subjects using dual energy X-ray absorptiometry (DXA). The BMD of RA patients was assessed according to patients' age and menopause and was compared with age-matched controls for various activity factors of RA and duration of the disease that might correlate with BMD. At stages I and II of premenopausal RA, generalised osteoporosis was not observed. At stages III and IV, the BMD decreased considerably in premenopausal RA patients at age of 45 years or older. There were significant correlations between the BMD of postmenopausal RA and all factors examined, many of which did not affect premenopausal RA. These results suggest that osteoporosis of female patients with RA is influenced only slightly by the disease itself, but it is secondary osteoporosis induced by decreased activities of daily living due to RA.
采用双能X线吸收法(DXA)对181例类风湿关节炎(RA)女性患者和255例对照者的桡骨骨密度(BMD)进行了测量。根据患者年龄和绝经情况对RA患者的BMD进行评估,并与年龄匹配的对照者就可能与BMD相关的RA各种活动因素及病程进行比较。在绝经前RA的I期和II期,未观察到全身性骨质疏松。在III期和IV期,45岁及以上的绝经前RA患者BMD显著下降。绝经后RA患者的BMD与所有检查因素之间存在显著相关性,其中许多因素对绝经前RA没有影响。这些结果表明,RA女性患者的骨质疏松症仅受疾病本身的轻微影响,而是由RA导致的日常生活活动减少所引起的继发性骨质疏松症。