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Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-alpha 4 antibody in adjuvant arthritis.

作者信息

Barbadillo C, G-Arroyo A, Salas C, Mulero J, Sánchez-Madrid F, Andreu J L

机构信息

Servicio de Reumatología, Hospital Puerta de Hierro, Madrid, Spain.

出版信息

Springer Semin Immunopathol. 1995;16(4):427-36. doi: 10.1007/BF00196098.

DOI:10.1007/BF00196098
PMID:7570293
Abstract
摘要

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Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-alpha 4 antibody in adjuvant arthritis.类风湿关节炎中的抗整合素免疫疗法：抗α4抗体在佐剂性关节炎中的保护作用
Springer Semin Immunopathol. 1995;16(4):427-36. doi: 10.1007/BF00196098.
2
[Prospects of immunotherapy in rheumatoid arthritis].[类风湿关节炎免疫治疗的前景]
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Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease.用抗CD18和极迟活化抗原-4整合素的单克隆抗体治疗大鼠已建立的佐剂性关节炎，可抑制中性粒细胞和T淋巴细胞向关节的迁移，并改善临床疾病。
Immunology. 1996 Aug;88(4):569-76. doi: 10.1046/j.1365-2567.1996.d01-695.x.
4
TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.类风湿关节炎中的肿瘤坏死因子阻断：对治疗和发病机制的影响
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Immunotherapy of rheumatoid arthritis.类风湿关节炎的免疫疗法
Ann Rheum Dis. 1992 May;51(5):577-9. doi: 10.1136/ard.51.5.577.
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Treatment with anti-NAP monoclonal antibody reduces disease severity in murine model of novel angiogenic protein-induced or ovalbumin-induced arthritis.抗 NAP 单克隆抗体治疗可减轻新型血管生成蛋白诱导或卵清蛋白诱导关节炎小鼠模型的疾病严重程度。
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Synergistic effects of interleukin-1β and interleukin-17A antibodies on collagen-induced arthritis mouse model.白细胞介素-1β 和白细胞介素-17A 抗体对胶原诱导性关节炎小鼠模型的协同作用。
Int Immunopharmacol. 2013 Feb;15(2):199-205. doi: 10.1016/j.intimp.2012.12.010. Epub 2012 Dec 29.
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Monoclonal antibody therapy in rheumatoid arthritis.类风湿关节炎的单克隆抗体疗法。
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The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo.α4整合素在体内慢性炎症的毛细血管后微静脉中支持白细胞滚动和黏附。
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Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis.
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The association between the lymphocyte-monocyte ratio and disease activity in rheumatoid arthritis.淋巴细胞-单核细胞比值与类风湿关节炎疾病活动度的相关性。
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Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism.缺氧和缺氧模拟物通过缺氧诱导因子依赖的机制抑制 5A32 内皮细胞系中 TNF 依赖性 VCAM1 诱导。
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本文引用的文献

1
Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.抗白细胞介素6单克隆抗体治疗重症类风湿关节炎
J Rheumatol. 1993 Feb;20(2):259-62.
2
Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response.针对整合素α-4亚基的单克隆抗体可抑制小鼠接触性超敏反应。
Eur J Immunol. 1993 Mar;23(3):682-8. doi: 10.1002/eji.1830230317.
3
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.一种识别极晚期活化抗原-4的单克隆抗体可在体内抑制嗜酸性粒细胞聚集。
针对VLA-4抑制剂的组合方法：哌嗪-类肽-双芳基脲
Mol Divers. 2000;5(2):61-73. doi: 10.1023/a:1013990624215.
4
Use of biologics in the treatment of childhood rheumatic diseases.生物制剂在儿童风湿性疾病治疗中的应用。
Curr Rheumatol Rep. 2000 Aug;2(4):330-6. doi: 10.1007/s11926-000-0071-1.
5
Cell-cell interactions in synovitis. Endothelial cells and immune cell migration.滑膜炎中的细胞间相互作用。内皮细胞与免疫细胞迁移。
Arthritis Res. 2000;2(5):368-73. doi: 10.1186/ar114. Epub 2000 Jul 3.
6
Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporin A.佐剂性关节炎大鼠关节和引流淋巴结中的细胞因子mRNA及环孢素A的作用
Inflammation. 2000 Oct;24(5):447-61. doi: 10.1023/a:1007064212462.
7
Adhesion molecules in inflammatory diseases.炎症性疾病中的黏附分子
Drugs. 1998 Dec;56(6):977-88. doi: 10.2165/00003495-199856060-00003.
8
Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease.用抗CD18和极迟活化抗原-4整合素的单克隆抗体治疗大鼠已建立的佐剂性关节炎，可抑制中性粒细胞和T淋巴细胞向关节的迁移，并改善临床疾病。
Immunology. 1996 Aug;88(4):569-76. doi: 10.1046/j.1365-2567.1996.d01-695.x.
J Exp Med. 1993 Feb 1;177(2):561-6. doi: 10.1084/jem.177.2.561.
4
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.用抗肿瘤坏死因子α嵌合单克隆抗体治疗类风湿性关节炎。
Arthritis Rheum. 1993 Dec;36(12):1681-90. doi: 10.1002/art.1780361206.
5
Chimeric CD4 monoclonal antibody cM-T412 as a therapeutic approach to rheumatoid arthritis.
Arthritis Rheum. 1993 Oct;36(10):1375-9. doi: 10.1002/art.1780361008.
6
Use of a chimeric monoclonal anti-CD4 antibody in patients with refractory rheumatoid arthritis.嵌合单克隆抗CD4抗体在难治性类风湿关节炎患者中的应用。
Arthritis Rheum. 1993 Mar;36(3):307-18. doi: 10.1002/art.1780360304.
7
Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment.合成纤连蛋白肽通过阻断白细胞黏附和募集来抑制大鼠关节炎。
J Clin Invest. 1994 Aug;94(2):655-62. doi: 10.1172/JCI117382.
8
Distinct patterns of expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial-leukocyte adhesion molecule-1 in renal disease.细胞间黏附分子-1、血管细胞黏附分子-1和内皮细胞-白细胞黏附分子-1在肾脏疾病中的不同表达模式。
Lab Invest. 1993 Sep;69(3):329-35.
9
Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.α4β7整合素介导B细胞与纤连蛋白及血管细胞黏附分子-1的结合。人B淋巴细胞上α4整合素的表达与功能。
J Immunol. 1993 Sep 1;151(5):2471-83.
10
Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1.α4β7整合素介导淋巴细胞与黏膜血管地址素MAdCAM-1的结合。
Cell. 1993 Jul 16;74(1):185-95. doi: 10.1016/0092-8674(93)90305-a.