Sano N, Takehara H, Udaka H, Izumi K
2nd Department of Pathology, School of Medicine, University of Tokushima, Japan.
Tokushima J Exp Med. 1995 Jul;42(1-2):37-40.
We report a case of undifferentiated (embryonal) sarcoma (USL) of the liver arising in a 5-year-old girl. She had abdominal pain and distension after a blow to her abdomen. Exploratory laparotomy disclosed a large tumor arising from left lobe of the liver, which showed a typical gross and microscopic appearance of USL. Immunohistochemically, the tumor cells reacted with antibodies against vimentin, cytokeratin, alpha-smooth muscle actin and muscle actin (HHF35). These immunohistochemical variety of the tumor cells may indicate unregulated gene expression of anaplastic tumor cells rather than divergent differentiation of immature cells as in hepatoblastoma.
我们报告了一例发生在一名5岁女孩身上的肝脏未分化（胚胎性）肉瘤（USL）。她在腹部受到撞击后出现腹痛和腹胀。剖腹探查发现一个巨大肿瘤起源于肝脏左叶，其具有USL典型的大体和显微镜下表现。免疫组化显示，肿瘤细胞与波形蛋白、细胞角蛋白、α-平滑肌肌动蛋白和肌动蛋白（HHF35）抗体发生反应。肿瘤细胞的这种免疫组化多样性可能表明间变性肿瘤细胞基因表达失控，而非像肝母细胞瘤那样是未成熟细胞的分化异常。
