人类钠离子依赖性磷酸盐共转运蛋白NaPi-3和NPT-1基因的染色体定位
Chromosome assignments of genes for human Na(+)-dependent phosphate co-transporters NaPi-3 and NPT-1.
作者信息
Miyamoto K, Tatsumi S, Yamamoto H, Katai K, Taketani Y, Morita K, Takeda E
机构信息
Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan.
出版信息
Tokushima J Exp Med. 1995 Jul;42(1-2):5-9.
Chromosome assignments for the genes encoding human renal high affinity Na/phosphate co-transporters NaPi-3 and NPT-1 were derived by analyzing somatic cell hybrid DNAs. Polymerase chain reaction (PCR), using primers specific for two human Na/Pi co-transporters demonstrated that the genes for NaPi-3 was assigned to human chromosome 5 while that for NPT-1 was assigned to human chromosome 6. Renal phosphate transporter genes may be candidates for causing hereditary hypophosphatemia with hypercalciuria in humans.
通过分析体细胞杂交DNA，确定了编码人类肾脏高亲和力钠/磷酸盐协同转运蛋白NaPi-3和NPT-1的基因的染色体定位。使用针对两种人类钠/磷酸盐协同转运蛋白的特异性引物进行聚合酶链反应（PCR），结果表明，NaPi-3基因定位于人类5号染色体，而NPT-1基因定位于人类6号染色体。肾脏磷酸盐转运蛋白基因可能是导致人类遗传性低磷血症伴高钙尿症的候选基因。
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