Blakey D H, Nestmann E R, Bayley J M, Maus K L, Douglas G R
Mutagenesis Section, Department of National Health and Welfare, Ottawa, Ontario, Canada.
Toxicol Ind Health. 1992 Nov-Dec;8(6):369-76.
Toluenesulfonhydrazide (TSH) is a high volume production chemical for which there is relatively little toxicological data. In this study, the mutagenic activity of TSH was determined in the Salmonella/mammalian microsome assay and the in vitro chromosomal aberration assay using Chinese hamster ovary cells. TSH induced gene mutations both with and without metabolic activation in the Salmonella/mammalian microsome assay but that it did not induce chromosomal aberrations in Chinese hamster ovary cells. The results of this study indicate that TSH is an in vitro mutagen and should be assessed for in vivo mutagenicity.
对甲苯磺酰肼（TSH）是一种大量生产的化学品，其毒理学数据相对较少。在本研究中，通过沙门氏菌/哺乳动物微粒体试验以及使用中国仓鼠卵巢细胞的体外染色体畸变试验，测定了TSH的诱变活性。在沙门氏菌/哺乳动物微粒体试验中，无论有无代谢活化，TSH均能诱导基因突变，但在仓鼠卵巢细胞中，它未诱导染色体畸变。本研究结果表明，TSH是一种体外诱变剂，应对其体内诱变性进行评估。
