Nakagawa Y, Nishimura K, Oikawa N, Kurihara N, Ueno T
Department of Agricultural Chemistry, Kyoto University, Japan.
Steroids. 1995 May;60(5):401-5. doi: 10.1016/0039-128x(94)00065-k.
Ecdysone analogs with various side chains at the 17-position of the steroid structure enhanced the incorporation of N-acetylglucosamine as 20-hydroxyecdysone into the cultured integument prepared from Chilo suppressalis. Their activity in terms of the concentration required to give 50% of the maximum response varied with the structure. Piperonyl butoxide, an inhibitor of oxidation metabolism, did not enhance the in vitro effect of the compounds. The order of potency was ponasterone A > 20-hydroxyecdysone > cyasterone > inokosterone > makisterone A >> ecdysone.
在甾体结构的17位带有不同侧链的蜕皮激素类似物，能增强N-乙酰葡糖胺作为20-羟基蜕皮激素掺入到由二化螟制备的培养体壁中。就产生最大反应的50%所需的浓度而言，它们的活性随结构而变化。氧化代谢抑制剂胡椒基丁醚不会增强这些化合物的体外效应。效力顺序为：波那甾酮A＞20-羟基蜕皮激素＞杯甾酮＞蜕皮甾酮＞玛氏甾酮A＞＞蜕皮激素。
