Chartier C, Pors I, Benoit C
CNEVA, Station Régionale de Pathologie Caprine, Niort, France.
Vet Parasitol. 1995 Aug;59(1):69-73. doi: 10.1016/0304-4017(94)00737-w.
The efficacy of pyrantel tartrate was evaluated in goats against induced infections with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis. All the strains were of sheep origin and tested for susceptibility to pyrantel tartrate in sheep at the standard dose rate (20 mg kg-1) prior to the infection of goats. Fifteen French Alpine female goats were inoculated with the three nematode species. On Day 25 post-infection, goats were randomized into an untreated control group and two pyrantel treatment groups (20 mg kg-1 bodyweight once, and 40 mg kg-1 bodyweight as two doses 24 h apart). The goats were killed and processed for worm recovery 10 days after treatment. The two dose rates achieved high and similar levels of efficacy (> 96%) against Haemonchus contortus and Teladorsagia circumcincta. Against Trichostrongylus colubriformis, however, pyrantel tartrate was less effective at both dose rates as worm reductions ranged from 55 to 62%.
评估了酒石酸噻嘧啶对山羊感染捻转血矛线虫、环形泰勒虫和蛇形毛圆线虫的疗效。所有菌株均来源于绵羊，在感染山羊之前，以标准剂量率（20 mg kg-1）对绵羊进行酒石酸噻嘧啶敏感性测试。15只法国阿尔卑斯母山羊接种了这三种线虫。感染后第25天，将山羊随机分为未处理对照组和两个酒石酸噻嘧啶治疗组（20 mg kg-1体重一次，40 mg kg-1体重分两剂，间隔24小时）。治疗10天后，将山羊处死并进行蠕虫回收处理。两种剂量率对捻转血矛线虫和环形泰勒虫均达到了高且相似的疗效水平（> 96%）。然而，对于蛇形毛圆线虫，两种剂量率的酒石酸噻嘧啶效果均较差，蠕虫减少率在55%至62%之间。
