Zechner O
Urologischen Abteilung, Wilhelminenspitals, Stadt Wien.
Wien Med Wochenschr. 1995;145(11-12):279-82.
Drug therapy in terms of prophylaxis of recurrent urolithiasis is known to be successful in inborn metabolic disturbances as cystinuria, primary hyperoxaluria, inborn errors of purine metabolism and calculi due to urinary infection. At the time efficient regimes for the large group of idiopathic urolithiasis are not available. The reason is that pathophysiology of urinary stone formation is still not fully understood. As a consequence of changing therapy in terms of extracorporal shockwave therapy and endourological lithotripsy, intensity of basic research in this field has markedly decreased. Optimizing prophylactic therapy of urolithiasis could only be achieved by development of completely new strategies from basic research.
就复发性尿路结石的预防而言，药物治疗在诸如胱氨酸尿症、原发性高草酸尿症、嘌呤代谢先天性缺陷以及由泌尿系统感染引起的结石等先天性代谢紊乱中已被证明是成功的。目前，针对大量特发性尿路结石患者尚无有效的治疗方案。原因在于尿路结石形成的病理生理学仍未被完全理解。由于体外冲击波疗法和腔内碎石术等治疗方法的不断变化，该领域基础研究的强度已显著降低。只有通过基础研究开发全新的策略，才能实现尿路结石预防性治疗的优化。
