Kulaev B S, Protas L L, Bursian A V, Semenova Iu O
Zh Evol Biokhim Fiziol. 1995 Jan-Feb;31(1):38-43.
In experiments on newborn rats it was shown that heart beating frequency depended on the intensity of interoceptive afferentation. Partial shutdown of the afferentation by means of intraperitoneal injection of novocaine in the dose of 25 mg/kg of body weight caused the increase of heart beating and the more complete one at higher doses (100 mg/kg of body weight) led to its decrease. The injection of 2% novocaine (150-200 mg/kg of body weight) into the peritoneum of rat puppies on the first week of life caused the transition of bradycardia into temporary or permanent stop of heart beating. The same effect was observed for isolated atrium of rat puppies on the first week of life after the addition of 0.1% novocaine to feeding solution. This effect disappeared in older animals. It was concluded that resorptive effect of novocaine on heart structures causing the disturbance of heart automatism in newborn rats occurred along with the reflex one.
在新生大鼠实验中表明，心跳频率取决于内感受性传入的强度。通过腹腔注射25毫克/千克体重剂量的奴夫卡因部分阻断传入，会导致心跳加快，而更高剂量（100毫克/千克体重）更完全的阻断则会导致心跳减慢。在出生后第一周向幼犬腹腔注射2%奴夫卡因（150 - 200毫克/千克体重）会使心动过缓转变为心跳暂时或永久停止。在出生后第一周的幼犬离体心房中，向培养液中添加0.1%奴夫卡因后也观察到了相同的效果。在年长动物中这种效果消失。得出的结论是，奴夫卡因对心脏结构的吸收作用导致新生大鼠心脏自动节律紊乱，这种作用与反射作用同时发生。
