Himoto Y, Kanzaki S, Nomura H, Araki T, Takahashi Y, Seino Y
Department of Pediatrics, Fukuyama Municipal Hospital, Japan.
Acta Paediatr Jpn. 1995 Aug;37(4):534-6. doi: 10.1111/j.1442-200x.1995.tb03371.x.
This is the first reported case, to our knowledge, of hypoparathyroidism and hypothyroidism due to secondary hemochromatosis with onset during childhood. The patient was a boy with refractory aplastic anemia in whom primary hypothyroidism and hypoparathyroidism became apparent at the age of 10 and 11 years old, respectively. He had received a total of 100 L of transfused blood by the age of 10 years. The patient showed poor annual height gain due to primary hypothyroidism, together with hypocalcemia, cataract and intracranial calcification due to hypoparathyroidism. The early appearance of both thyroid and parathyroid dysfunction in this patient may have been due to the delay of initiation of iron-chelating agents and liver dysfunction due to hepatitis type C.
据我们所知，这是首例报告的因继发性血色素沉着症在儿童期发病导致甲状旁腺功能减退和甲状腺功能减退的病例。该患者是一名患有难治性再生障碍性贫血的男孩，原发性甲状腺功能减退和甲状旁腺功能减退分别在10岁和11岁时显现。到10岁时，他总共接受了100升输血。由于原发性甲状腺功能减退，患者每年身高增长缓慢，同时因甲状旁腺功能减退出现低钙血症、白内障和颅内钙化。该患者甲状腺和甲状旁腺功能障碍的早期出现可能是由于铁螯合剂开始使用延迟以及丙型肝炎导致的肝功能障碍。
