Chen C H, Shen W C, Wang T M, Chi C S
Department of Pediatrics, Taichung Veterans General Hospital, Taiwan, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1995 Jul-Aug;36(4):261-5.
A total of 17 very-low-birth-weight (range from 625-1500 grams) preterm infants received brain magnetic resonance imaging (MRI) study at a mean corrected age of 23 months (range from 15-33 months). They were classified into two groups. In Group 1 (12 cases) the cranial ultrasound study was normal during infancy. There were two cases with typical change of periventricular leukomalacia (PVL) detected by MRI study; both showed spastic diplegia. In Group 2 (five cases) ultrasound study was abnormal during infancy while the MRI confirmed the change of PVL in these cases whose ultrasound study showed typical change of PVL. In two cases of intraventricular hemorrhage (IVH) Grade I and III separately, the MRI also revealed the change of PVL, but only the case of IVH grade III had spastic diplegia. The myelination process of all cases were completed as normal term infants. In conclusion, brain MRI confirmed the PVL change discovered by cranial ultrasound and the results were strongly correlated with spastic type cerebral palsy. For those infants with an abnormal neurological examination, MRI may be useful for diagnosis of PVL in spite of normal ultrasound findings during the newborn period.
共有17名极低出生体重（625 - 1500克）的早产儿在平均矫正年龄23个月（15 - 33个月）时接受了脑磁共振成像（MRI）研究。他们被分为两组。在第1组（12例）中，婴儿期头颅超声检查正常。MRI研究检测到2例有典型的脑室周围白质软化（PVL）改变；二者均表现为痉挛性双瘫。在第2组（5例）中，婴儿期超声检查异常，而MRI证实这些超声检查显示PVL典型改变的病例存在PVL改变。在2例分别为Ⅰ级和Ⅲ级脑室内出血（IVH）的病例中，MRI也显示有PVL改变，但只有IVHⅢ级的病例有痉挛性双瘫。所有病例的髓鞘形成过程与足月儿一样正常完成。总之，脑MRI证实了头颅超声发现的PVL改变，且结果与痉挛型脑瘫密切相关。对于那些神经学检查异常的婴儿，尽管新生儿期超声检查结果正常，但MRI可能有助于PVL的诊断。
