常氧、高氧和缺氧对内淋巴PO2及耳蜗电位影响的相关性。

A correlation of the effects of normoxia, hyperoxia and anoxia on PO2 of endolymph and cochlear potentials.

作者信息

Prazma J, Fischer N D, Biggers W P, Ascher D

出版信息

Hear Res. 1978 Oct;1(1):3-9. doi: 10.1016/0378-5955(78)90003-5.

Abstract

Change in PO2 in endolymph, endocochlear potentials and cochlear microphonics have been tested in normoxia, hyperoxia and anoxia on 24 guinea pigs. The polarographic method and construction of oxygen-sensitive microelectrodes is described in detail. The normal level of PO2 in endolymph vaires between 20 and 30 mm Hg. One-minute anoxia induced by breathing 100% N2 caused a decline in PO2, EP and CM, but during recovery only PO2 returned with over-correction to the preexposure level. Hyperoxia evoked by breathing 100% oxygen failed to increase the cochlear potentials and the PO2 in the endolymph. This suggests that vasoconstriction most likely occurs proximal to the capillaries bed of the stria vascularis.

摘要

在常氧、高氧和缺氧条件下，对24只豚鼠的内淋巴中的氧分压（PO2）变化、耳蜗内电位和耳蜗微音电位进行了测试。详细描述了极谱法和氧敏感微电极的构建。内淋巴中PO2的正常水平在20至30毫米汞柱之间变化。呼吸100%氮气引起的1分钟缺氧导致PO2、耳蜗内电位（EP）和耳蜗微音电位（CM）下降，但在恢复过程中只有PO2过度校正后恢复到暴露前水平。呼吸100%氧气引起的高氧未能增加耳蜗电位和内淋巴中的PO2。这表明血管收缩很可能发生在血管纹毛细血管床的近端。