Madsen J S, Svalastoga E
Department of Clinical Studies, Small Animal Hospital, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark.
Acta Vet Scand. 1995;36(1):157-60. doi: 10.1186/BF03547714.
The aim of the present study was to investigate the use of procollagen type III aminoterminal peptide (PIIINP) measurements in serum as an indicator of progress of fibrosis of coxofemoral joint capsules in hip dysplasia in immature dogs. High serum concentrations of PIIINP may indicate ongoing fibrosis with enhanced synthesis and deposition of fibrillar type III collagen, or an alteration in degradation and elimination of circulating PIIINP ( 1988a). Therefore, high concentrations of PIIINP in serum was expected in dogs with hip dysplasia, which is a developmental condition with capsular fibrosis and osteoarthritis ( 1986).
本研究的目的是调查血清中III型前胶原氨基端肽（PIIINP）测量值作为未成熟犬髋关节发育不良时髋股关节囊纤维化进展指标的用途。血清中高浓度的PIIINP可能表明存在持续性纤维化，伴有III型纤维状胶原的合成和沉积增加，或者循环中PIIINP的降解和清除发生改变（1988a）。因此，预计患有髋关节发育不良的犬血清中PIIINP浓度会升高，髋关节发育不良是一种伴有关节囊纤维化和骨关节炎的发育性疾病（1986）。
