Haas G J, McCune S A, Brown D M, Cody R J
Division of Cardiology, College of Medicine, Ohio State University Medical Center, Columbus 43210, USA.
Am Heart J. 1995 Oct;130(4):806-11. doi: 10.1016/0002-8703(95)90081-0.
This study uses echocardiography to characterize the pattern of left ventricular hypertrophy in a new hypertensive heart failure-prone rat strain designated SHHF/Mcc-cp (SHHF). M-mode echocardiograms of the left ventricle in nine 10- to 12-month old SHHF rats and nine age-matched spontaneously hypertensive rats (SHR) were compared. Wistar-Kyoto and Sprague-Dawley strains served as the normotensive control group. SHHF rats had significantly greater left ventricular mass than did rats in the normotensive control group. Although left ventricular mass was not different between SHHF and SHR, significant differences were seen in the pattern of left ventricular remodeling as determined by relative wall thickness. These differences in left ventricular remodeling may explain the earlier development of heart failure in SHHF. The different patterns of left ventricular hypertrophy in SHHF and SHR suggests that heart failure in SHHF is not mediated by hypertension alone.
本研究采用超声心动图来描述一种新的易发生高血压性心力衰竭的大鼠品系SHHF/Mcc-cp（SHHF）的左心室肥厚模式。比较了9只10至12月龄SHHF大鼠和9只年龄匹配的自发性高血压大鼠（SHR）左心室的M型超声心动图。Wistar-Kyoto和Sprague-Dawley品系作为正常血压对照组。SHHF大鼠的左心室质量显著高于正常血压对照组的大鼠。虽然SHHF和SHR之间的左心室质量没有差异，但通过相对壁厚度确定的左心室重构模式存在显著差异。左心室重构的这些差异可能解释了SHHF中心力衰竭的早期发生。SHHF和SHR中左心室肥厚的不同模式表明，SHHF中的心力衰竭并非仅由高血压介导。
