Newman R S, Fagin A R
Department of Pathology, U.C. Irvine Medical Center, Orange 92613-4091, USA.
Am J Clin Pathol. 1995 Oct;104(4):447-9. doi: 10.1093/ajcp/104.4.447.
Artifactual heparin contamination of blood samples drawn for coagulation testing is an ongoing problem. A retrospective analysis of activated partial thromboplastin times (APTTs) greater than 45 seconds from patients on neither heparin nor Coumadin (Dupont, Wilmington, DE) therapy shows complete correction of the APTT to normal in 39% of such samples after treatment with heparinase. Recheck of samples with significantly prolonged APTTs after treatment with heparinase is proposed as the best method to avoid inappropriate transfusion of fresh frozen plasma.
用于凝血检测的血液样本出现人为肝素污染是一个长期存在的问题。对未接受肝素或香豆素（杜邦公司，特拉华州威尔明顿）治疗且活化部分凝血活酶时间（APTT）大于45秒的患者进行回顾性分析发现，在使用肝素酶治疗后，此类样本中有39%的APTT完全恢复正常。建议在使用肝素酶治疗后对APTT显著延长的样本进行复查，这是避免不适当输注新鲜冰冻血浆的最佳方法。
