Raab S S, Isacson C, Layfield L J, Lenel J C, Slagel D D, Thomas P A
University of Iowa, Iowa City, USA.
Am J Clin Pathol. 1995 Nov;104(5):574-82. doi: 10.1093/ajcp/104.5.574.
Histologic follow-up of the cervical-vaginal smear diagnosis of atypical glandular cells of undetermined significance (AGUS) shows a broad spectrum of clinically significant (preneoplastic or neoplastic) and benign lesions. There are few statistical studies that have attempted to separate these AGUS categories based on select cytologic criteria. The authors retrospectively reviewed 116 AGUS without concurrent squamous dysplasia smears (66 clinically significant and 50 benign lesions), and used logistic regression analysis to identify the cytologic criteria of irregular nuclear membranes, atypical single cells, and decreased cytoplasm as useful in separating clinically significant from benign lesions. Using contingency tables, these criteria in combination had a sensitivity 29% and a specificity of 94% in the diagnosis of clinically significant lesions. If any single criterion was present, the sensitivity and specificity were 100% and 28%, respectively. In conclusion, by using key cytologic criteria, a percentage of benign AGUS lesions can be separated from clinically significant AGUS lesions.
对宫颈阴道涂片诊断为意义不明确的非典型腺细胞（AGUS）进行组织学随访，结果显示存在一系列具有临床意义（癌前或肿瘤性）和良性的病变。很少有统计研究尝试根据特定的细胞学标准来区分这些AGUS类别。作者回顾性分析了116例无并发鳞状上皮发育异常涂片的AGUS病例（66例具有临床意义的病变和50例良性病变），并使用逻辑回归分析来确定核膜不规则、非典型单个细胞和细胞质减少这些细胞学标准，有助于区分具有临床意义的病变和良性病变。通过列联表分析，这些标准联合使用时，在诊断具有临床意义的病变方面，敏感性为29%，特异性为94%。如果存在任何单一标准，敏感性和特异性分别为100%和28%。总之，通过使用关键的细胞学标准，可以将一部分良性AGUS病变与具有临床意义的AGUS病变区分开来。
