Leite L P, Just R J, Castell D O, Lagerström P O
Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania, USA.
Am J Gastroenterol. 1995 Oct;90(10):1874-7.
Successful omeprazole therapy in patients with symptomatic gastroesophageal reflux (GER) refractory to treatment with H2-receptor antagonists has often been reported. In contrast, successful treatment of GER by H2-receptor antagonists in patients resistant to the acid-suppressing effects of omeprazole is rarely reported. We describe two patients who demonstrated therapeutic responses to high dose H2-receptor antagonists after high dose omeprazole failed to suppress gastric acidity and GER.
