一个新的X连锁智力障碍（MRX20）家系中的短串联重复序列多态性连锁研究
Short tandem repeat polymorphism linkage studies in a new family with X-linked mental retardation (MRX20).
作者信息
Lazzarini A, Stenroos E S, Lehner T, McKoy V, Gold B, McCormack M K, Reid C S, Ott J, Johnson W G
机构信息
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903, USA.
出版信息
Am J Med Genet. 1995 Jul 17;57(4):552-7. doi: 10.1002/ajmg.1320570407.
A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.
对一个没有其他明显表现的X连锁隐性智力迟钝（XLMR）家族（MRX20）使用14个短串联重复多态性（STRP）标记进行了研究。使用DXS1003、DXYS1、DXS3和DXS458获得了高于3的两点连锁值。在DXS1003处出现峰值，获得了4.25的多点连锁值。重组事件确定了DXS1068和DXS454之间55.6厘摩的区间，而一个单位支持区间确定了MAOA和DXS458之间40厘摩的区间。
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