Byerley W, Holik J, Hoff M, Coon H
Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132, USA.
Am J Med Genet. 1995 Jun 19;60(3):231-3. doi: 10.1002/ajmg.1320600312.
Six kindreds containing multiple cases of Manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21. The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree [Straub et al., 1993: The American Society of Human Genetics]. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance. The nonparametric affected sib pair test did not yield significant evidence of linkage.
