唑尼沙胺与苯妥英钠和丙戊酸钠的药物相互作用：血清浓度与蛋白结合率

Drug interactions of zonisamide with phenytoin and sodium valproate: serum concentrations and protein binding.

作者信息

Tasaki K, Minami T, Ieiri I, Ohtsubo K, Hirakawa Y, Ueda K, Higuchi S

机构信息

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Brain Dev. 1995 May-Jun;17(3):182-5. doi: 10.1016/0387-7604(95)00032-7.

DOI:10.1016/0387-7604(95)00032-7

PMID:7573757

Abstract

The influence of co-medication with zonisamide (ZNS) on the serum concentration and protein binding of phenytoin (PHT) and sodium valproate (VPA) was studied in 21 pediatric patients. No significant correlation between the daily ZNS dose, and total serum concentrations, free concentrations or free fractions (FF) of PHT or VPA was observed. The patient study showed that changes in the FF of PHT and VPA were correlated more closely with the serum protein and bilirubin levels than changes in the ZNS dosage. An in vitro study revealed that the addition of ZNS caused decreases in the FF of PHT and VPA. However, these decreases were within the range of measurement error and were negligible. In conclusion, no significant effect of ZNS on the serum concentration or protein binding of PHT or VPA was demonstrated.

摘要

在21名儿科患者中研究了唑尼沙胺（ZNS）联合用药对苯妥英（PHT）和丙戊酸钠（VPA）血清浓度及蛋白结合率的影响。未观察到ZNS日剂量与PHT或VPA的总血清浓度、游离浓度或游离分数（FF）之间存在显著相关性。患者研究表明，PHT和VPA的FF变化与血清蛋白和胆红素水平的相关性比与ZNS剂量变化的相关性更密切。一项体外研究显示，添加ZNS会导致PHT和VPA的FF降低。然而，这些降低在测量误差范围内，可忽略不计。总之，未证明ZNS对PHT或VPA的血清浓度或蛋白结合有显著影响。