氯氮平用于青少年迟发性运动障碍

Clozapine for tardive dyskinesia in adolescents.

作者信息

Levkovitch Y, Kronenberg J, Kayser N, Zvyagelski M, Gaoni B, Gadoth N

机构信息

Shalvata-Mental Health Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

出版信息

Brain Dev. 1995 May-Jun;17(3):213-5. doi: 10.1016/0387-7604(95)00034-9.

DOI:10.1016/0387-7604(95)00034-9

PMID:7573764

Abstract

Thousands of adolescents use neuroleptic drugs over extended periods of time for a wide range of mental disorders. One of the most severe adverse effects of neuroleptic drugs is tardive dyskinesia (TD), for which no successful treatment is currently available. Clozapine is a known atypical neuroleptic drug with few extrapyramidal side effects. It has been suggested that clozapine may be beneficial for the treatment of tardive dyskinesia in adolescents. However, the efficacy of the drug in adolescents is unknown. This report describes the beneficial effect of clozapine on tardive dyskinesia in two adolescents with schizophrenia.

摘要

数千名青少年长期使用抗精神病药物来治疗各种各样的精神障碍。抗精神病药物最严重的不良反应之一是迟发性运动障碍（TD），目前尚无成功的治疗方法。氯氮平是一种已知的非典型抗精神病药物，几乎没有锥体外系副作用。有人提出氯氮平可能对治疗青少年迟发性运动障碍有益。然而，该药物在青少年中的疗效尚不清楚。本报告描述了氯氮平对两名患有精神分裂症的青少年迟发性运动障碍的有益作用。